What about large rooms as well as rooms where the listener is far from the speakers?

Typical in-wall speakers are designed to be near the listener. In common rooms with eight foot ceilings and other usual dimensions, in-wall speakers typically are not much more than eight feet from the listener. In large mansions, the game changes. Twenty foot ceilings are normal and typical speakers are too far away to provide the client much SPL (sound pressure level). There are in-wall speakers designed for these longer "throw" distances. In general, larger rooms with more height require more speakers and speakers with tighter "directivity" to get party-level SPL. In this case, also, size matters and bigger speakers are better.